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opentargets-mcp
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opentargets-mcp

Active·★ 19·MIT·Updated 2026-10-09

This project provides a Model Context Protocol (MCP) server, integrating the Open Targets Platform GraphQL API to offer a comprehensive suite of tools. It enables AI agents and MCP-compatible clients like Claude Desktop to access and analyze diverse biomedical data for drug discovery and target validation.

#Open Targets#MCP Server#GraphQL API#Biomedical Data#Drug Discovery#Target Analysis
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Guides
#AI Agents
#Python
$ Install
$ git clone https://github.com/nickzren/opentargets-mcp && cd opentargets-mcp && pip install uv && uv sync
↗ Visit site★ GitHub
01

Features

01Target Analysis: Search genes/proteins, access expression data, genetic constraints, pathways, protein interactions, safety profiles, and mouse phenotypes.
02Disease Analysis: Query diseases by EFO ID, find associated targets, phenotypes (HPO), and research projects.
03Drug Discovery: Search drugs by ChEMBL ID, access safety data, adverse events, indications, and mechanism of action.
04Evidence Mining: Explore target-disease associations with scored evidence from multiple genetic, functional, and literature sources.
05Cross-Entity Workflows: Utilize multi-hop tools that chain disease, target, and drug evidence for prioritization and complex queries.
02

Compatibility

Python
Runtime
Verified via docs
Docker
Containerization
Verified via docs
Claude Desktop
Client Integration
Verified via docs
Web MCP Clients
Client Integration
Verified via docs
03

Quick start

1
$ git clone https://github.com/nickzren/opentargets-mcp
2
$ cd opentargets-mcp
3
$ pip install uv
4
$ uv sync
04

Use cases

↳Integrating Open Targets data with AI agents for complex biomedical queries and interactive exploration.
↳Providing structured Open Targets tools for Claude Desktop and other MCP-compatible clients.
↳Facilitating drug repurposing and target prioritization workflows using curated data and tools.
↳Performing detailed target, disease, and drug profiling and analysis based on comprehensive data sources.
↳Developing custom integrations and scripts that leverage the Open Targets Platform GraphQL API.
05

Alternatives

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VSrelace-mcp★33→VSmcp★983→VSmcp-redis★638→

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nickzren /
opentargets-mcp
↗

MCP server for Open Targets Data

19MIT
Last commit2w ago
StatusActive
CategoryRAG / Knowledge Base
Links
Documentation↗Discussion↗Issues↗Releases↗
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