OnCo
★ 237
vs
letta
★ 25.2k
OnCo vs letta
OnCo: OnCo is an open, cited knowledge graph dedicated to cancer, aiming for total information dominance across all aspects of the disease. It provides a comprehensive repository of data, research, treatments, and patient information accessible via a website, static JSON API, and command-line tools.; letta: Letta is a powerful platform for building stateful AI agents equipped with advanced memory, enabling them to learn and self-improve over time. It provides both a command-line interface for local agent execution and a comprehensive API with Python and TypeScript SDKs for seamless integration into applications.
01
TL;DR
OnCoRAG / Knowledge Base · ★ 237
Patients and Carers: Access plain-English information on cancers, treatments, side effects, and evidence-graded complementary approaches.
lettaMemory & Context · ★ 25.2k
When to choose:
- You want a long-lived agent that remembers past work and rewrites its own memory and context over time.
- You want one agent reachable from CLI, desktop, browser, mobile and messaging apps, with subagents, schedules and hooks.
- You want memory you can inspect: the README says context is tracked in git and can sync to your own repository.
When to skip:
- You only need to add memory to an agent you already use through MCP; a small MCP memory server is a lighter fit.
- You rely on older Letta tutorials or the V1 API server: the project restructured, and the V1 server is retired.
- You want everything to work without signing in: Letta Cloud is the default backend and some features need it.
02
Side-by-Side Comparison
Field
OnColettaCategory
RAG / Knowledge Base
Memory & Context
Stars
★ 237
★ 25.2k
License
MIT
Apache-2.0
Install Command
npx onco
npm install -g @letta-ai/letta-code
Updated
1d ago
5d ago
Open Source
Yes
Yes
Tags
Oncology, Knowledge Graph, Cancer Research
Stateful AI, Agent Platform, Advanced Memory
03
Features
OnCo01Interactive Website Interface: Offers filters, tooltips, molecule renderings, a graph explorer, and an 'Ask OnCo' question answering system.
02Static JSON API: Provides programmatic access to the corpus with CORS, Markdown context files for language models, Atom feeds, and RDF triples.
03Command-Line Tool (CLI) and MCP Server: Enables agents and scripts to search, fetch, compare, and query the cancer corpus directly.
04Multi-language Support: Offers eight interface languages with translated TL;DRs to enhance accessibility for a global audience.
letta01Build stateful AI agents with advanced memory
02Agents capable of learning and self-improvement over time
03CLI tool for running agents locally in your terminal
04Comprehensive API for integrating agents into applications
05Support for skills and subagents; fully model-agnostic
04
Use Cases
OnCo↳Patients and Carers: Access plain-English information on cancers, treatments, side effects, and evidence-graded complementary approaches.
↳Clinicians and Researchers: Explore the state of the art, history, ongoing research, and bottlenecks in cancer, with direct links to primary sources.
↳AI Agents and Scripts: Programmatically search, fetch, compare, and query the knowledge graph for data integration, analysis, and LLM context.
↳Investors and Policymakers: Understand market landscapes, treatment approvals by region, funding, and the overall progress in oncology.
letta↳Running AI agents locally in your terminal for coding and general tasks.
↳Integrating stateful AI agents into custom applications using the API and SDKs.
↳Developing self-improving AI systems that adapt and learn continually.
05
Best For
OnCoHidden Gem
lettaMost PopularEssentialTrending
FAQ
FAQ
What is the difference between OnCo and letta?
Both OnCo and letta are in the RAG / Knowledge Base category. OnCo has 237 stars, while letta has 25.2k stars.
Which is better, OnCo or letta?
The best choice depends on your use case. Choose OnCo if Patients and Carers: Access plain-English information on cancers, treatments, side effects, and evidence-graded complementary approaches., and letta if Running AI agents locally in your terminal for coding and general tasks..
Is OnCo free or open source?
Yes, OnCo is open source on GitHub (MIT).
Is letta free or open source?
Yes, letta is open source on GitHub (Apache-2.0).
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