opentargets-mcp
Active·★ 17·MIT·Updated 2026-05-15
★ Trending★ API Integration
MCP server for Open Targets Data
This project provides a Model Context Protocol (MCP) server, integrating the Open Targets Platform GraphQL API to offer a comprehensive suite of tools. It enables AI agents and MCP-compatible clients like Claude Desktop to access and analyze diverse biomedical data for drug discovery and target validation.
#Open Targets#MCP Server#GraphQL API#Biomedical Data#Drug Discovery#Target Analysis#AI Agents#Python
01
Features
01Target Analysis: Search genes/proteins, access expression data, genetic constraints, pathways, protein interactions, safety profiles, and mouse phenotypes.
02Disease Analysis: Query diseases by EFO ID, find associated targets, phenotypes (HPO), and research projects.
03Drug Discovery: Search drugs by ChEMBL ID, access safety data, adverse events, indications, and mechanism of action.
04Evidence Mining: Explore target-disease associations with scored evidence from multiple genetic, functional, and literature sources.
05Cross-Entity Workflows: Utilize multi-hop tools that chain disease, target, and drug evidence for prioritization and complex queries.
02
Compatibility
Python
Runtime
Verified via docs
Docker
Containerization
Verified via docs
Claude Desktop
Client Integration
Verified via docs
Web MCP Clients
Client Integration
Verified via docs
03
Quick start
1
$ git clone https://github.com/nickzren/opentargets-mcp
2
$ cd opentargets-mcp
3
$ pip install uv
4
$ uv sync
04
Use cases
↳Integrating Open Targets data with AI agents for complex biomedical queries and interactive exploration.
↳Providing structured Open Targets tools for Claude Desktop and other MCP-compatible clients.
↳Facilitating drug repurposing and target prioritization workflows using curated data and tools.
↳Performing detailed target, disease, and drug profiling and analysis based on comprehensive data sources.
↳Developing custom integrations and scripts that leverage the Open Targets Platform GraphQL API.
05
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Comments
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- TTaylor ZhangMay 9, 2026
Good for bioinformaticians and computational biology teams using Open Targets.
- HHarper KimMay 7, 2026
Target identification and disease association queries through natural language.
- DDrew BrownApr 8, 2026
Open Targets drug target and disease data via MCP for AI-assisted drug discovery.
- SSam JohnsonApr 1, 2026
Works with Open Targets' public API for authoritative biological data.